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目的观察多西紫杉醇联合5-氟尿嘧啶(5-FU)、顺铂(DDP)方案治疗中晚期胃癌的疗效和毒副反应。方法采用多西紫杉醇75mg/m2,静脉滴注,第1天。顺铂75mg/m2,静脉滴注,第1天。5-FU750mg/(m2.d),24h持续静滴,第1～5天,行2周期治疗后判定疗效并随访。结果36例均可评价疗效,其中完全缓解(CR)1例(2.78%),部分缓解(PR)16例(44.44%),稳定(SD)18例(50.00%),进展(PD)1例(2.78%),有效率为(CR+PR)47.22%。平均生存时间5.3个月。毒副反应以骨髓抑制、脱发和消化道反应为主,其它毒副反应相对较少,并可耐受,无化疗相关死亡。结论多西紫杉醇为主方案治疗中晚期胃癌疗效肯定,毒副反应能耐受,值得进一步在临床使用观察。
Objective To observe the efficacy and side effects of docetaxel combined with 5-fluorouracil (5-FU) and cisplatin (DDP) in the treatment of advanced gastric cancer. Methods docetaxel 75mg / m2, intravenous drip, the first day. Cisplatin 75mg / m2, intravenous infusion, the first day. 5-FU750mg / (m2.d), 24h continuous intravenous infusion, 1 to 5 days, 2 lines after treatment to determine the efficacy and follow-up. Results All of the 36 cases were evaluated for efficacy, including complete remission (CR) in 1 case (2.78%), partial remission (PR) in 16 cases (44.44%), stable (SD) in 18 cases (2.78%), the effective rate was (CR + PR) 47.22%. The average survival time of 5.3 months. Toxicity to bone marrow suppression, hair loss and gastrointestinal reactions, other relatively few side effects, and can be tolerated, no chemotherapy-related deaths. Conclusion Docetaxel-based regimen for the treatment of advanced gastric cancer with certain effect, toxic side effects can tolerate, it is worth further observation in clinical use.