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目的:了解抗感染药致老年人药品不良反应(ADR)的情况,分析其相关因素。方法:回顾性调查分析我院2004年1月～2009年12月收集上报的ADR报告中,抗感染药致老年人ADR的特点和规律。结果:抗感染药致老年人ADR共331例,占上报ADR例数的9.87%。涉及抗感染药为14类55个品种,喹诺酮类药物引起的ADR占首位,其中以左氧氟沙星为主;给药途径主要为静脉给药;以皮肤及附件的损害最常见。结论:抗感染药致老年ADR与抗感染药的种类、给药途径、给药剂量等多种因素相关,临床上给老年人使用抗感染药时应注意合理用药,以减少或避免老年人ADR的发生。
Objective: To understand the adverse drug reaction (ADR) induced by anti-infectives in the elderly and analyze the related factors. Methods: The retrospective investigation of our hospital from January 2004 to December 2009 collected reports of ADR reported anti-infectives induced ADR characteristics and patterns. Results: A total of 331 ADR patients were induced by anti-infectives, accounting for 9.87% of the reported ADR cases. The anti-infectives were classified into 14 categories and 55 varieties. Quinolones caused the most serious ADRs, of which levofloxacin was the main route of administration, and the routes of administration were mainly intravenous. The most common lesions were skin and appendages. Conclusion: ADR induced by anti-infectives is related to many factors such as the type of anti-infectives, the route of administration and the dosage of anti-infectives. In the clinical use of anti-infectives, reasonable medication should be taken to reduce or avoid ADR in the elderly happened.