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目的:探讨HLA基因与成人急性淋巴细胞白血病(ALL)发病之间的关联。方法:采用序列特异性引物聚合酶链反应(PCR蛳SSP)DNA分型技术,对105 例成人急性淋巴细胞白血病患者和142名正常对照进行HLA基因分型,分析HLA基因分布频率在2组中的差异。结果:ALL组与正常对照组相比,A鄢0201(35.71 %)和B鄢4801(5.71 %)基因频率明显增高(RR=2.340 7、7.513 4,χ2=9.257 8、9.538 8 P<0.005),DRB1鄢0701基因频率(9.52 %)显著低于正常组(RR=0.439 2,χ2=6.990 2 P<0.01)。结论:HLA蛳B鄢4801和DRB1鄢0701基因可分别被认为是ALL白血病发病的危险标志和保护标志。
Objective: To explore the relationship between HLA gene and adult acute lymphoblastic leukemia (ALL). Methods: HLA genotyping was performed in 105 adult patients with acute lymphoblastic leukemia and 142 normal controls using sequence-specific primer polymerase chain reaction (PCR 蛳 SSP) genotyping. HLA genotyping frequencies were analyzed in two groups The difference. Results: The frequencies of A 0201 (35.71%) and 4801 (5.71%) B allele in ALL group were significantly higher than those in normal control group (RR = 2.340 7,7.513 4, χ2 = 9.257 8,9.538 8 P <0.005) , The frequency of DRB1 Yan 0701 gene was significantly lower than that of normal group (RR = 0.439 2, χ2 = 6.990 2 P <0.01). Conclusion: HLA 蛳 B Yan 4801 and DRB1 Yan 0701 genes may be considered as risk markers and protective markers of ALL leukemia respectively.