论文部分内容阅读
目的 探讨全身炎症反应综合征 (SIRS)患者抗炎症细胞因子对T淋巴细胞 (简称T细胞 )凋亡的影响。方法 符合SIRS诊断 42例 ,分别在入院当天和第 2、 4天清晨空腹抽肘静脉血 3ml,测定转化细胞生长因子 β (TGF β)、白介素 1 0 (IL 1 0 )和CD3+T细胞、CD95+T细胞 ,并设对照组。结果 TGF β和IL 1 0入院第 1天起持续升高 ,与对照组比较差异有显著性意义 (P <0 0 1 ) ;CD3+T细胞和CD95+T细胞入院当天即降低 ,第 2天后更低 ,与对照组比较差异有显著性意义 (P <0 0 5 ,P <0 0 1 ) ;TGF β与CD3+T细胞、CD95+T细胞具有显著的相关性 (r =- 0 71 5 ,- 0 672 ) ;IL 1 0与CD3+T细胞、CD95+T细胞呈显著的相关性 (r=- 0 597,- 0 60 4 )。结论 抗炎因子诱导T淋巴细胞凋亡增加 ,总数减少和免疫功能紊乱 ;适度拮抗抗炎症细胞因子 ,使致炎因子与抗炎因子达到平衡 ,可能有利于SIRS的控制
Objective To investigate the effect of anti-inflammatory cytokines on the apoptosis of T lymphocytes (T cells) in patients with systemic inflammatory response syndrome (SIRS). Methods According to the SIRS diagnosis, 42 cases were diagnosed by the SIRS method. 3ml elbow vein blood was collected on the day of admission and on the 2nd and 4th days respectively. The levels of TGFβ, IL-10 and CD3 + CD95 + T cells, and set the control group. Results The levels of TGF β and IL 10 kept rising on the first day after admission, which was significantly different from the control group (P 0 01). The levels of CD 3 + T cells and CD 95 + T cells decreased on the day of admission, (P <0.05, P <0.01). There was a significant correlation between TGFβ and CD3 + T cells and CD95 + T cells (r = -0.715 , -0672). There was a significant correlation between IL-10 and CD3 + T cells and CD95 + T cells (r = - 0 597, - 0 60 4). Conclusion Anti-inflammatory cytokines induce an increase of T lymphocyte apoptosis, a decrease of the total number and immune dysfunction. Moderate antagonism of anti-inflammatory cytokines and balance of proinflammatory cytokines and anti-inflammatory cytokines may be beneficial to the control of SIRS