论文部分内容阅读
目的 :研究心房颤动 (atrialfibrillation ,AF)时心房肌的电生理重构。方法 :快速持续起搏犬右心房 8～ 10周 ,制备持续性AF模型。比较对照犬 ( 8只 )与起搏犬 ( 10只 )的有效不应期 (effectiverefractoryperiod ,ERP)和心房颤动波周长 (atrialfibrillationcyclelength ,AFCL)的变化来分析心房肌的电生理重构。结果 :起搏组P波时间和PA间期比起搏前明显延长 (P波时间 90 5± 10 5对 5 3 6± 8 3ms ;PA间期 5 9 6± 8 8对 3 8 6± 11 4ms ,P <0 0 5 )。经程序刺激ERP较对照组明显缩短 (S1S13 0 0ms 115± 2 3对 15 0± 2 1;S1S14 0 0ms 10 5± 2 7对 15 4± 2 4ms ,P <0 0 5 )。同一心房不同部位的ERP和AFCL也存在差异。结论 :心房率的长期变化可引起ERP和AFCL的变化 ,即心房肌发生电生理重构 ,而且不同部位心房肌电生理重构是不同的。
Objective: To study the electrophysiological remodeling of atrial fibrillation in atrial fibrillation (AF). Methods: The dog sustained right atrial pacing for 8 to 10 weeks to prepare a continuous AF model. The electrophysiological remodeling of atrial myocardium was compared between the effective refractory period (ERP) and the atrial fibrillation cycle length (AFCL) of control dogs (8 dogs) and pacemakers (10 dogs). Results: P wave time and PA interval in pacing group were significantly longer than before pacing (P wave time 90 5 ± 10 5 vs 53 6 ± 8 3 ms; PA interval 5 9 6 ± 8 8 vs 3 8 6 ± 11 4ms, P <0 0 5). ERP was significantly shorter than that of the control group (S1S13 0 ms115 ± 23 vs15 0 ± 21; S1S14 0 ms10 5 ± 2 7 vs15 4 ± 2 ms, P <0 05). Different parts of the same atrial ERP and AFCL there are differences. CONCLUSIONS: Long-term changes in atrial rate lead to changes in ERP and AFCL, ie, electrophysiological remodeling of the atrium, and the electrophysiological remodeling of atrial myocytes is different in different locations.