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目的探讨米非司酮联合甲氨蝶呤与单纯甲氨蝶呤治疗宫外孕的疗效。方法选择2014年6月~2016年2月我院收治的宫外孕患者68例作为研究对象,将其随机分为对照组与治疗组,对照组单纯应用甲氨蝶呤治疗,治疗组应用米非司酮联合甲氨蝶呤治疗,比较两组患者的疗效。结果治疗组包块与腹痛消失时间以及阴道止血时间均要明显优于对照组,差异有统计学意义(P<0.05);治疗组治愈率为94.1%,对照组治愈率为76.5%,两组对比,差异有统计学意义(P<0.05);治疗组不良反应发生率为17.6%,对照组不良反应发生率为26.5%,两组不良反应发生率对比,差异无统计学意义(P>0.05)。结论宫外孕应用米非司酮联合甲氨蝶呤治疗的疗效要显著优于单纯应用甲氨蝶呤治疗,值得临床推广应用。
Objective To investigate the efficacy of mifepristone combined with methotrexate and methotrexate in the treatment of ectopic pregnancy. Methods Sixty-eight patients with ectopic pregnancy who were admitted to our hospital from June 2014 to February 2016 were selected as study subjects and randomly divided into control group and treatment group. The control group was treated with methotrexate alone. The treatment group was treated with mifepristone Ketone combined methotrexate treatment, the efficacy of the two groups were compared. Results The disappearance time of the mass and abdominal pain and the time of vaginal bleeding in the treatment group were significantly better than those in the control group (P <0.05). The cure rate was 94.1% in the treatment group and 76.5% in the control group. The two groups (P <0.05). The incidence of adverse reactions in the treatment group was 17.6%, while that in the control group was 26.5%. There was no significant difference in the incidence of adverse reactions between the two groups (P> 0.05) ). Conclusion Ectopic pregnancy with mifepristone combined with methotrexate treatment was significantly better than the simple use of methotrexate treatment, it is worthy of clinical application.