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目的通过检测重型颅脑外伤后的病人的T细胞亚群、免疫球蛋白的变化,了解重型颅脑损伤患者的免疫功能状况。方法于入院第1、3、7、15天采血检测患者T细胞亚群(CD3、CD4、CD8、CD4/CD8)、免疫球蛋白(IgA、IgG、IgM)水平。结果重型颅脑损伤患者T细胞亚群在受伤第1天就出现明显抑制,之后逐渐好转,CD3在第7、15天,CD4在第15天,CD4/CD8在第15天较第1天有明显上升;同时体液免疫功能也明显受抑制,IgG、IgA明显下降(P<0.01),随治疗的进展两周后基本恢复正常。结论重型颅脑损伤后免疫功能持续降低,其对治疗的反应将影响病人的预后及感染的控制。
Objective To detect the changes of T cell subsets and immunoglobulins in patients with severe craniocerebral trauma and to understand the immune function of patients with severe craniocerebral injury. Methods The levels of T lymphocyte subsets (CD3, CD4, CD8, CD4 / CD8) and immunoglobulins (IgA, IgG, IgM) were detected on the 1st, 3rd, 7th and 15th days after admission. Results T cell subsets in patients with severe craniocerebral injury showed obvious inhibition on the first day of injury and then gradually improved. CD3 was on the 7th and 15th days, CD4 was on the 15th day, CD4 / CD8 was on the 15th day compared with the first day Significantly increased; humoral immune function was significantly inhibited, IgG, IgA decreased significantly (P <0.01), with the treatment of two weeks after the basic return to normal. Conclusion The immune function continues to decrease after severe craniocerebral injury, and its response to treatment will affect the prognosis of patients and the control of infection.