作者曾于1981年报道,将从尸检胰腺组织提取的β—内啡肽(经放射免疫检测法及凝胶色谱法鉴定并定量)静脉注射到正常成人体内,能刺激胰岛素和胰高血糖素释放,继而伴发高血糖症。同时还证明,这种存在在于胰腺D细胞内的β—内啡肽参与糖代谢的调节。本文报道了外源性β—内啡肽对不依赖胰岛素型糖尿病患者(Ⅱ型糖尿病)的胰岛素和胰高血糖素的释放,以及对血糖值的影响。 The authors reported in 1981 that beta-endorphin extracted from autopsy pancreatic tissue (identified and quantitated by radioimmunoassay and gel chromatography) was injected intravenously into normal adults to stimulate insulin and glucagon release , Followed by hyperglycemia. It has also been demonstrated that this is due to the involvement of β-endorphin in pancreatic D cells in the regulation of glucose metabolism. This article reports the release of insulin and glucagon exogenous β-endorphin in patients with type 2 diabetes (insulin-dependent diabetes mellitus) and its effect on blood glucose levels.