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目的 :阐明白细胞介素 - 1对病理性瘢痕效应的作用机理。 方法 :观察白细胞介素 - 1对病理性瘢痕成纤维细胞超微结构的影响。 结果 :该介素明显破坏了线粒体、粗面内质网、核糖体等重要细胞器。 结论 :证明白细胞介素 - 1是成纤维细胞合成胶原的负性调节因子
Objective: To clarify the mechanism of action of interleukin - 1 on pathological scarring. Methods: The effect of interleukin - 1 on the ultrastructure of fibroblasts of pathological scar was observed. Results: The interleukin obviously destroyed important organelles such as mitochondria, rough endoplasmic reticulum and ribosome. Conclusion: IL - 1 is proved to be a negative regulator of fibroblast synthesis of collagen