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目的讨论并分析在慢性阻塞性肺病急性加重期治疗中,全身应用甲强龙联合尼可刹米的临床效果。方法选取2011年3月至2012年2月四川省江安县中医医院收治的60例慢性阻塞性肺病患者。采用随机分组的方式将患者分为观察组和对照组,观察组行全身应用甲强龙联合尼可刹米治疗,对照组行常规治疗。结果经过系统治疗,观察组患者第一秒用力呼气容积(FEV1)/用力肺活量(FVC)和FEV1均要明显优于对照组,差异有统计学意义(P<0.05)。结论在慢性阻塞性肺病急性加重期的治疗中,全身应用甲强龙联合尼可刹米具有一定的临床价值。
Objective To discuss and analyze the clinical effect of systemic administration of metformin combined with nikethamide in the treatment of acute exacerbation of chronic obstructive pulmonary disease. Methods From March 2011 to February 2012, 60 patients with chronic obstructive pulmonary disease were admitted to Jiang’an Hospital of Traditional Chinese Medicine in Sichuan Province. The patients were randomly divided into observation group and control group. The observation group was treated with methylprednisolone and nikethamide, and the control group received routine treatment. Results After systematic treatment, the FEV1 / FVC and FEV1 in the observation group were significantly better than those in the control group (P <0.05). Conclusion In the treatment of acute exacerbation of chronic obstructive pulmonary disease, systemic administration of methylprednisolone combined with nikethamide has certain clinical value.