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目的:探讨腹水与血清癌胚抗原(CEA)水平及其比值对恶性腹水的诊断价值。方法:检测50例恶性、50例良性腹水患者的腹水和血清CEA水平,并分别计算其腹水与血清CEA比值。结果:恶性组腹水及血清CEA水平和其比值均显著高于良性组。恶性组病人腹水CEA水平显著高于其血清CEA水平。分别以腹水CEA水平大于19.67 μg/L、血清CEA水平大于15.01 μg/I_、腹水与血清CEA之比大于2.01作为恶性腹水的诊断标准,在本研究100例中3种标准诊断恶性腹水的敏感度、特异度和准确度分别为腹水CEA:32%、92％、62%);血清CEA:28％、90％、59％;腹水与血清CEA之比:66％、94％、80％,其中腹水与血清CEA之比敏感度和准确度均显著高于腹水CEA和血清CEA标准。结论:观察腹水和血清CEA之比更有助于恶性腹水的诊断。
Objective: To investigate the diagnostic value of ascites and serum carcinoembryonic antigen (CEA) levels and its ratio in malignant ascites. Methods: The ascites and serum CEA levels in 50 patients with malignant ascites and 50 patients with benign ascites were detected. The ratio of ascites to serum CEA was calculated. Results: The malignant ascites and serum CEA levels and their ratios were significantly higher than those in the benign group. CEA levels in ascites in patients with malignant disease were significantly higher than those in serum CEA. CEA levels of ascites more than 19.67 μg / L, serum CEA levels greater than 15.01 μg / I_, ascites and serum CEA ratio of greater than 2.01 as malignant ascites diagnostic criteria in the study of 100 cases of three criteria for the diagnosis of malignant ascites sensitivity , Specificity and accuracy were ascites CEA: 32%, 92%, 62%); serum CEA: 28%, 90%, 59%; ascites and serum CEA ratio: 66%, 94%, 80% Ascites and serum CEA ratio sensitivity and accuracy were significantly higher than the ascites CEA and serum CEA standards. Conclusion: It is more helpful to observe the ratio of ascites to serum CEA in the diagnosis of malignant ascites.