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目的 探讨酸性谷胱甘肽S -转移酶 (GST -π)和p5 3蛋白在肺癌中表达的临床病理意义和相关性。方法 应用LSAB免疫组化法对 60例肺癌组织GST -π和p5 3蛋白的表达进行研究。结果 肺癌中GST -π和p5 3蛋白的阳性率分别为5 6 67%和 3 1 67%。GST -π和p5 3蛋白表达与肿瘤分化程度明显相关 ,高中分化肺癌阳性率明显高于低分化及未分化者 (P <0 0 5 )。GST -π与p5 3蛋白表达呈明显正相关 (r =0 3 75 ,P <0 0 5 ) ,p5 3蛋白阳性者中GST -π阳性率高于p5 3蛋白阴性者。结论 GST -π和p5 3蛋白异常表达可能与肺癌的发生发展有关。检测GST -π表达对预测肺癌多药耐药、化疗疗效有一定的价值
Objective To investigate the clinicopathological significance and correlation of the expression of glutathione S-transferase (GST-π) and p5 3 protein in lung cancer. Methods The expression of GST-π and p53 protein in 60 cases of lung cancer tissues were studied by LSAB immunohistochemical method. Results The positive rates of GST-π and p5 3 in lung cancer were 56 67% and 31 67% respectively. The expression of GST-π and p5 3 protein was significantly correlated with the degree of tumor differentiation. The positive rate of high differentiation lung cancer was significantly higher than that of poorly differentiated and undifferentiated (P <0.05). The expression of GST-π was positively correlated with the expression of p5 3 protein (r = 0 3 75, P 0 05). The positive rate of GST-π in p5 3 protein positive group was higher than that of p5 3 protein. Conclusion The abnormal expression of GST-π and p53 proteins may be related to the occurrence and development of lung cancer. Detection of GST-π expression in predicting lung cancer multidrug resistance, chemotherapy has a certain value