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实验用成年Wistar大鼠35只,随机分为7组:假手术组,胆管结扎(CBDL)组,CBDL+生理盐水腹腔注射组,CBDL+654-2治疗组,CBDL+生理盐水灌胃组,CBDL+胆盐治疗组,CBDL+乳果糖治疗组。术后第8天开始给药,连续给药至术后第21天活杀,切取肾脏行病理学观察。结果显示:胆管结扎组近曲小管上皮细胞普遍呈明显的浊肿及水泡变性,可见整个肾小管坏死,有些区域可见肾小管呈片状坏死;654-2治疗组仅见部分近曲小管上皮细胞呈浊肿及水泡变性;而胆盐及乳果糖灌胃组与生理盐水灌胃组病变基本一致,表现为肾小管大片状坏死。因此,作者认为胆道梗阻时654-2对肾脏有明显的保护作用,而胆盐及乳果糖并无明显作用。
Thirty-five adult Wistar rats were randomly divided into 7 groups: sham operation group, CBDL group, CBDL + saline intraperitoneal injection group, CBDL + 654-2 treatment group, CBDL + saline administration group, CBDL + Salt treatment group, CBDL + lactulose treatment group. After the first eight days after administration, continuous administration to 21 days after surgery to kill, cut the kidneys pathological observation. The results showed that the proximal tubule epithelial cells in the bile duct ligation group generally showed obvious turbidity and blister degeneration, which showed that the entire tubular necrosis, tubule necrosis was observed in some areas; only some of the proximal tubule epithelial cells were seen in the 654-2 treatment group Turbidity and blisters degeneration; and bile salts and lactulose gavage group and saline gavage group lesions basically the same, manifested as tubular necrosis. Therefore, the authors believe that 654-2 biliary obstruction has a significant protective effect on the kidneys, while bile salts and lactulose did not have a significant effect.