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目的了解肝硬化患者血小板参数和凝血指标的变化,探讨其临床应用价值。方法检测70例肝硬化患者血小板参数及凝血指标,并与70例健康对照组的各项指标进行比较。结果 1肝硬化出血组及未出血组与健康对照组比较,血小板(PLT)、血小板比容(PCT)显著下降,血小板平均体积(MPV)及血小板分布宽度(PDW)显著增高(P<0.05),而肝硬化出血组与未出血组比较,以上指标差异均有统计学意义(P<0.05);2肝硬化患者凝血酶原时间(PT)、凝血酶时间(TT)及活化部分凝血活酶时间(APTT)较健康对照组明显延长,而纤维蛋白原(FIB)显著下降。结论测定肝硬化患者血小板参数及凝血指标可有效判断肝功能损害程度,为指导临床用药、判断预后和降低出血风险及病死率提供重要依据。
Objective To understand the changes of platelet parameters and coagulation indexes in patients with cirrhosis and to explore its clinical value. Methods The platelet parameters and coagulation indexes of 70 patients with cirrhosis were detected and compared with those of 70 healthy controls. Results 1 Compared with the healthy control group, the PLT and PCT decreased significantly, and the mean platelet volume (MPV) and platelet distribution width (PDW) increased significantly (P <0.05) , While there was significant difference in the above indexes between cirrhotic and non-hemorrhagic groups (P <0.05); 2 Prothrombin time (PT), thrombin time (TT) and activated partial thromboplastin Time (APTT) was significantly longer than the healthy control group, while fibrinogen (FIB) decreased significantly. Conclusion The determination of platelet parameters and coagulation parameters in patients with cirrhosis can effectively determine the extent of liver dysfunction and provide an important basis for guiding clinical medication, prognosis and reducing the risk of bleeding and mortality.