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Objective To study the potential role of macrophage migration inhibitory factor ( MIF),Interleukin-17 (IL-17) and lnterleukin-10 (IL-10) in the development of HBV-related liver disease.Methods 48 patients with chronic hepatitis B ( HBeAg negative and positive,24 cases; 21 cases of HBV-DNA negative and 27 cases of HBV-DNA positive),81 cases of hepatitis B patients with decompensated cirrhosis and 48 cases of primary liver cancer patients were collected as the experimental group,26 healthy people were as control group.Serum MIF,IL-17 and IL-10 were measured.Results MIF and IL-17 significantly increased,IL-10 significantly decreased in experimental group,compared with the control group ( P ＜ 0.05 ),there was significant difference. In addition,there was no significant difference (P ＞0.05) between positive and negative of chronic hepatitis B.MIF,IL-17 and ALT levels were positively correlated ( r =0.693,P ＜ 0.0 1 ; r =0.897,P ＜ 0.001 ),IL-10 and ALT was negatively correlated ( r =-0.285,P =0.037).Conclusion These results indicated that MIF,IL-17 and IL-10 may participate in the pathological process of HBV-related liver disease,serum levels of MIF,IL-17 and IL-10 appear to reflect the severity of tissue injury in HBV-related liver disease.