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目的研究垂体瘤的临床特征及常规病理和超微结构改变。方法回顾研究４３２例经蝶窦手术治疗垂体肿瘤的临床特点，其中１１９例术中鞍底硬膜活检，光镜检查４２４例，免疫组化检查２９例，电镜检查１０３例，临床结合病理进行分析研究。结果发现鞍区非泌乳素（ＰＲＬ）垂体腺瘤同样可以产生高泌乳素血症；鞍底硬膜有瘤细胞浸及７８例（６５５％）。结论（１）高泌乳素血症并非泌乳素腺瘤所特有，在诊断中应注意鉴别；（２）鞍底硬膜受肿瘤浸及是垂体腺瘤侵袭邻近组织的一个重要标志，与无硬膜浸及者相比，治疗有效率有显著性差异，复发率高，和预后密切相关；（３）根据病情选择合适的疗法，可获得满意效果。
Objective To study the clinical features, conventional pathology and ultrastructural changes of pituitary adenomas. Methods The clinical features of 432 cases of transsphenoidal surgery for pituitary tumors were retrospectively reviewed. Among them, 119 cases were performed subdural dural biopsy, 424 cases were examined by light microscopy, 29 cases were immunohistochemically examined, and 103 cases were examined by electron microscopy. the study. The results showed that non-prolactin (PRL) pituitary adenomas in the sellar area also produced hyperprolactinemia; tumor cells in the subdural dura mater were immersed in 78 cases (65.5%). Conclusions (1) Hyperprolactinemia is not endemic to prolactinoma, and should be discriminated in the diagnosis; (2) Sinusoid dural immersion is an important sign of pituitary adenoma invasion in adjacent tissues, and no hard Membrane leaching compared with those who have significant difference in treatment efficiency, high recurrence rate, and prognosis are closely related; (3) According to the condition of the appropriate choice of therapy, can obtain satisfactory results.