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目的 了解我国南方婴幼儿轮状病毒VP7、VP4型感染性腹泻的流行及临床特征。方法 对 1994年 11月～ 1997年 10月连续 3 6个月收集 10 99例病毒性腹泻患儿粪便标本行聚丙烯酰胺凝胶电泳 (PAGE)检测 ,阳性者行VP7、VP4型别鉴定、临床分析。结果 10 99例粪便标本进行PAGE检测 ,检出轮状病毒 50 1例 ,阳性率45.6%。定型为VP7型 2 71例 ,VP7G1型 2 3 3例 ,占总数 86% ;其次为G2、G3型 ,未发现G4型。定型为VP4193例 ,VP41A型 160例 ,占总数 83 % ;其次为 1B及 2型 ,未发现 3型。高发季节为 11月至次年 2月 ,1岁内VP41A型的发病率比VP7G1型多 ,前者为 73 % ,后者为 57%。 2岁时发病率相似 ,分别为 93 .1%和 90 .1%。VP7G1型高热较其他型高 2 7% ,而VP41A型低热比例最高 (占 91% ) ,VP41A、1B绝大部分 (98%、96% ) ,伴轻度脱水。而VP7G1型中度脱水多见。VP41A型大便在 10次 /d以上。电解质紊乱情况VP7较VP4型较重。结论 1994～ 1997年广州地区轮状病毒型别集中在VP7G1及VP4A1型 ,流行季节为 11月至次年 2月 ,但病例终年不断。临床表现方面VP7G1型比VP41A型感染重 ,治疗效果理想 ,预后良好
Objective To understand the prevalence and clinical features of infantile rotavirus VP7 and VP4 infectious diarrhea in southern China. Methods A total of 1099 children with viral diarrhea were enrolled in this study. Polyacrylamide gel electrophoresis (PAGE) was performed on stool samples of 10 99 children with viral diarrhea for consecutive 36 months from November 1994 to October 1997. Positive samples were identified as VP7 and VP4, analysis. Results 1099 cases of stool specimens were detected by PAGE, rotavirus 50 cases were detected in 50 cases, the positive rate of 45.6%. There were 2 71 cases of VP7 type and 233 cases of VP7G1 type, accounting for 86% of the total, followed by G2 and G3 types, but no G4 type was found. There were 1419 cases of VP419 and 160 cases of VP41A, accounting for 83% of the total, followed by 1B and 2 cases, and no cases of type 3 were found. High incidence season from November to February next year, 1-year-old incidence of VP41A type than VP7G1 type, the former was 73%, the latter was 57%. The incidence was similar at age 2 years, 93.1% and 90.1%, respectively. VP7G1 fever was 27% higher than other types, while VP41A had the highest low fever (91%) and VP41A and 1B mostly (98%, 96%) with mild dehydration. The moderate dehydration VP7G1 type more common. VP41A stool in 10 times / d or more. Electrolyte disorders VP7 heavier than the VP4 type. Conclusions From 1994 to 1997, the genotypes of rotavirus in Guangzhou were concentrated in VP7G1 and VP4A1, and the epidemic season was from November to February. However, the number of cases continued throughout the year. Clinical manifestations VP7G1 type than VP41A type of infection, the treatment effect is good, the prognosis is good