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新近有人用蛋白A免疫吸附治疗柱治疗血小板<100 000/μl的ITP,目的是去除病人血浆中的IgG和含IgG的循环免疫复合物(CIC)。初步的研究主要用于与人类免疫缺陷病毒(HIV)相关的血小板减少病人,免疫吸附治疗在减少CIC和血小板自身抗体,增加第二抗体(在体外它可中和自身抗体活性)的水平和使血小板计数正常方面发挥作用。作者总结了用蛋白A免疫吸附治疗柱治疗难治的ITP的体会。病人和方法72例病人中男27例、女45例。这些病人用皮质类固醇和脾切除无效,或在>6个月的期间内至少对两种治疗无效,血小板<50 000/μl,无其他引起血小板低的病因如脾大、感染、用药或肿瘤等,骨髓活检巨核细胞
A protein A immunoadsorption treatment column has recently been used to treat ITP with platelets <100 000 / μl to remove IgG and IgG circulating immune complexes (CICs) from the patient’s plasma. Preliminary studies are primarily aimed at patients with thrombocytopenia associated with the human immunodeficiency virus (HIV). Immunosuppressive therapy reduces the levels of CIC and platelet autoantibodies, increases the secondary antibody that neutralizes autoantibody activity in vitro Platelet count normal aspects play a role. The authors summarize the experience with protein A immunoadsorption treatment of refractory ITP. Patients and Methods There were 27 males and 45 females in 72 patients. These patients were ineffective with corticosteroids and splenectomy or were ineffective for at least two treatments for> 6 months, platelets <50,000 / μl, and none of the other causes of low platelets such as splenomegaly, infections, medication, or tumors , Bone marrow biopsy megakaryocytes