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目的 :探讨可溶性E 选择素 (sE selectin)在冠心病 (CHD)中的临床意义及其对心脏缺血性胸痛与非心脏缺血性胸痛的鉴别诊断价值。方法 :用ELISA法检测了 72例经冠状动脉造影 (CAG)诊断的胸痛患者血清sE selectin水平 ,并以 18例健康体检者作为对照。结果 :CAG阳性组sE selectin水平〔(6 8.4± 17.8) μg/L〕较CAG阴性组〔(5 4 .6± 19.6 ) μg/L〕及对照组〔(5 2 .8± 17.4 ) μg/L〕均明显增高 (P <0 .0 5 ) ,尤以急性心肌梗死患者增高更为显著〔(74 .3± 18.6 ) μg/L〕。以≥ 6 0 μg/L为低限 ,其诊断CHD的敏感性为 74 % ,特异性为 83%。 结论 :CHD患者血清sE selectin水平增高 ,并反映病情严重程度 ,可作为可疑胸痛患者的辅助鉴别诊断手段
Objective: To investigate the clinical significance of sE selectin in the diagnosis of coronary heart disease (CHD) and to evaluate the differential diagnosis of ischemic chest and non-cardiac ischemic chest pain. Methods: The serum levels of sE selectin in 72 patients with chest pain diagnosed by coronary angiography (CAG) were detected by ELISA. 18 healthy controls were used as controls. Results: The levels of sE selectin in CAG-positive group were significantly higher than those in CAG-negative group [(54.4 ± 19.6) μg / L〕 〔(54.2 ± 17.8) μg / L〕 〔 L] were significantly higher (P <0.05), especially in patients with acute myocardial infarction increased more significantly 〔(74.3 ± 18.6) μg / L〕. With a low limit of ≥ 60 μg / L, the sensitivity for diagnosing CHD was 74% with a specificity of 83%. Conclusion: The serum levels of sE selectin in patients with CHD are elevated, and reflect the severity of the disease, which can be used as auxiliary differential diagnosis in patients with suspected chest pain