当前抗血吸虫药物还不够理想,依然存在着疗效与毒性的矛盾,对感染较重者经一个治程还不能把全部成虫消灭,特别是在基本消灭了血吸虫病的地区,粪检检出率低,直肠活检多数不能判断体内是否还有活虫,血吸虫环卵试验环沉率亦低,又未见其他血清学诊断方法用于确定诊断或考核疗效,这对有病史的病人是否需复治带来了困难。据资料统计,晚期血吸虫病的出现,有治疗史者约占25～75％。为了预防晚期血吸虫病的出现,在这类地区,对这类型病人的复治问题,急待解决。我们于1975～1978年开展了这项工作,现将初步结果报告如下: The current anti-schistosome drugs are not ideal enough, there is still the contradiction between efficacy and toxicity, for those infected by a course of treatment can not eliminate all adults, especially in areas basically eliminated schistosomiasis, stool detection rate is low , The majority of rectal biopsy can not determine whether there are live in vivo, Schistosoma japonicum test egg loop test rate is also low, and no other serological diagnostic methods used to determine the diagnosis or assessment of curative effect, which patients with a history of need for retreatment It’s difficult. According to statistics, the emergence of advanced schistosomiasis, there is a history of treatment of about 25 to 75%. In order to prevent the emergence of advanced schistosomiasis, retreatment problems of this type of patients are urgently solved in such areas. We did this work from 1975 to 1978, and we report the preliminary results as follows: