大量的证据表明,间充质干细胞(MSC)可以通过旁分泌或自分泌发挥治疗作用,其疗效与血管生成、免疫调节及细胞凋亡有关。MSC分泌组即MSC所分泌的生物活性分子的总和,包括细胞因子、趋化因子和生长因子等多种活性成分,对损伤组织的修复、再生及功能恢复等许多生理过程具有调控作用。在创伤治疗领域,基于MSC分泌组研制的制剂极有可能成为替代MSC治疗的新疗法。 Numerous evidences indicate that mesenchymal stem cells (MSCs) can play a therapeutic role through paracrine or autocrine effects, and their effects are related to angiogenesis, immune regulation and apoptosis. MSC secretory group that MSC secretion of bioactive molecules, including cytokines, chemokines and growth factors and other active ingredients, the repair of damaged tissue, regeneration and functional recovery and many other physiological processes have a regulatory role. In the field of wound healing, preparations developed based on the MSC secretion group are very likely to become new therapies that will replace MSC treatment.