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目的 探讨抑癌基因P 15与肾癌生物学行为的关系。方法 采用免疫组织化学 (SP)方法对 5 0例肾癌组织和2 5例癌旁肾组织中P 15基因的表达进行检测。结果 癌旁肾组织中P 15阳性率 (76 % )显著高于肾癌组织 (48% ;P <0 0 5 )。随着肾癌病理分级、临床分期的上升 ,P 15表达阳性率明显降低。P 15阳性率在Ⅰ、Ⅱ、Ⅲ级肿瘤中分别为 6 6 7%、4 7 6 %和18 2 % (P <0 0 5 ) ;在Ⅰ、Ⅱ、Ⅲ -Ⅳ期肿瘤中分别为 6 1 9%、4 7 1%和 2 5 % (P <0 0 5 )。P 15阳性与阴性表达组间 3、5a生存率均存在显著性差异 (P <0 0 5 )。结论 抑癌基因P 15在防止肾癌的发生、发展中起重要作用 ,可用为肾癌生物学行为及预后的参考指标
Objective To investigate the relationship between the tumor suppressor gene P 15 and the biological behavior of renal cell carcinoma. Methods Immunohistochemistry (SP) was used to detect the expression of P 15 gene in 50 cases of renal cell carcinoma and 25 cases of adjacent normal renal tissues. Results The P 15 positive rate (76%) in paracancer tissues was significantly higher than that in renal cell carcinoma (48%; P 0 05). With the pathological grade and clinical stage of renal cell carcinoma, the positive rate of P 15 expression decreased significantly. The positive rate of P 15 was 66.7%, 47.6% and 18.2% (P <0.05) in grade Ⅰ, Ⅱ and Ⅲ tumors, respectively, and was significantly higher in patients with stage Ⅰ, Ⅱ and Ⅲ-Ⅳ tumors 19%, 471% and 25%, respectively (P <0 05). There was a significant difference in the survival rates of 3,5a between P 15 positive and negative groups (P <0.05). Conclusion The tumor suppressor gene P 15 plays an important role in preventing the occurrence and development of renal cell carcinoma and can be used as a reference index for the biological behavior and prognosis of renal cell carcinoma