寻找和发现新的肿瘤相关抗原,并观察其在人体内的分布、表达规律和生物学功能对于研究肿瘤的发病机理和防治措施具有重要的意义,也是肿瘤早期诊断及监测复发的重要课题。近年,随着单克隆抗体技术和分子生物学技术的广泛应用,肿瘤相关抗原的研究有了很大的进展,大多数学者认为肿瘤相关抗原只是一种与肿瘤相关的现象,其本质可极其多样。就其化学本质而言多为糖脂和糖蛋白(或蛋白多糖),就某些意义而言,肿瘤状态就是异常糖化状态,其 Looking for and discovering new tumor-associated antigens, and observing their distribution in the human body, the expression rules and biological functions are of great significance for studying the pathogenesis and prevention and treatment of tumors, and are also important topics in the early diagnosis and recurrence of tumors. In recent years, with the widespread use of monoclonal antibody technology and molecular biology techniques, great progress has been made in the research of tumor-associated antigens. Most scholars think that tumor-associated antigens are only tumor-related phenomena and can be extremely diverse in nature . In terms of their chemical nature, they are mostly glycolipids and glycoproteins (or proteoglycans). In some senses, the state of the tumor is the abnormal glycation state, which