皮肤角朊细胞的生长有 2条通路 :分化通路和激活通路。正常情况下 ,角朊细胞进入分化通路。伤口愈合及多种皮肤病理情况下 ,角朊细胞被激活 ,成为能够迁移的、具有高度增殖能力的细胞 ,分泌大量的细胞外基质和信号肽 ,同时角蛋白表达也发生改变。皮肤损伤后 ,角朊细胞经历一个周期性的激活过程 ,此过程受大量细胞因子作用及调节。激活后的角朊细胞能够表达特异角蛋白K6 ,K16和K17,其可以作为区分基底细胞是正常分化还是激活的标志物 There are 2 pathways for the growth of keratinocytes in the skin: the differentiation pathways and the activation pathways. Under normal circumstances, keratinocytes enter the differentiation pathways. In the case of wound healing and a variety of cutaneous pathologies, keratinocytes are activated to become migratory, highly proliferative cells that secrete large amounts of extracellular matrix and signal peptides, and that keratin expression also changes. After skin injury, keratinocytes undergo a cyclical activation process, which is regulated by a large number of cytokines. Activated keratinocytes are capable of expressing specific keratins K6, K16 and K17, which can serve as markers that distinguish basal cells from normal differentiation or activation