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目的：探讨脉络宁对糖尿病患者血小板活性的影响。方法：采用ＥＬＩＳＡ法和单克隆酶联免疫吸附法，检测３３ 例糖尿病患者和２８ 例正常对照者的血浆内血小板α颗粒膜蛋白（ＧＭＰ－ １４０）、血栓烷Ｂ２（ＴＸＢ２）、６－ 酮前列腺素Ｆ１α（６ｋｅｔｏＰＧＦ１α） 和血管性假血友病因子相关抗原（ＶＷＦ：Ａｇ） 含量。３３ 例糖尿病患者，１６ 例采用一般治疗，１７ 例在一般治疗基础上加用脉络宁，疗程３Ｗ。结果：糖尿病患者血浆ＧＭＰ－ １４０、ＴＸＢ２ 和ＶＷＦ：Ａｇ 含量明显高于对照组（Ｐ＜ ０．０１） ，６ － ｋｅｔｏ－ ＰＧＦ１α明显低于对照组（ Ｐ＜ ０．０１）；脉络宁治疗３Ｗ 后血浆ＧＭＰ－１４０ 和ＶＷＦ：Ａｇ 水平与治疗前比较明显下降（ Ｐ＜ ０．０１） ，ＴＸＢ２ 水平也明显下降（ Ｐ＜０．０５） ，６－ ｋｅｔｏ－ ＰＧＦ１α含量无显著变化。结论：糖尿病患者血小板处于明显活化状态，脉络宁对糖尿病患者的血小板活化具有明显抑制作用。
Objective: To investigate the effect of Mailuoning on platelet activity in diabetic patients. Methods: Plasma and platelet α-granule membrane protein (GMP-140), thromboxane B2 (TXB2), 6-keto-prostatic hyperplasia in 33 patients with diabetes mellitus and 28 normal controls were detected by ELISA and monoclonal antibody-linked immunosorbent assay F1α (6 keto PGF1α) and von Willebrand factor related antigen (VWF: Ag) content. 33 cases of diabetic patients, 16 cases of general treatment, 17 cases based on the general treatment with Mailuoning, treatment 3W. Results: The levels of plasma GMP - 140, TXB2 and VWF: Ag in diabetic patients were significantly higher than those in control group (P <0.01), and 6 - keto - PGF1α was significantly lower than that in control group (P <0.01) Plasma GMP-140 and VWF: Ag levels decreased significantly (P <0.01), TXB2 level decreased significantly (P <0.05), and the content of 6-keto-PGF1α had no significant change. Conclusion: Platelets in diabetic patients are obviously activated, and Mailuoning can significantly inhibit platelet activation in diabetic patients.