脑缺氧缺血性疾病为一类导致儿童病死率较高及严重后遗症的疾病,可由于窒息缺氧、脑血管畸形、脑外伤、心功能障碍及体循环血流量减少和血压下降等多因素所致。特别是窒息缺氧所致的新生儿缺氧缺血性脑病(HIE),不仅严重威胁新生儿的生命,而且可引起多种神经精神异常等后遗症。近年来,随着脑缺氧缺血性疾病发病机制研究的不断深入,已认识到机体 Hypoxic ischemic disease is a group of diseases that lead to high mortality and serious sequelae in children. Due to asphyxia, cerebrovascular malformations, traumatic brain injury, cardiac dysfunction and reduction of systemic blood flow and blood pressure, To In particular, neonatal hypoxic-ischemic encephalopathy (HIE) due to asphyxia and hypoxia not only seriously threaten the life of neonates, but also cause sequelae of various neuropsychiatric disorders. In recent years, with the deepening of the research on the pathogenesis of hypoxic-ischemic disease, it has been recognized that the body