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目的：观察氯氮平治疗精神分裂症患者的用药剂量与不良反应发生的情况并对其进行评估。方法：随机选择４５例住院的精神分裂症患者，以入院检查时躯体及实验室检查无异常，单用或并用氯氮平治疗者为对象，对他们的用药剂量，服药后不良反应发生情况进行统计学分析比较。结果：发现２８．７％出现锥体外系反应，此外氯氮平剂量大于４００ｋｇ·ｄ－１者的白细胞降低率明显高于剂量小于４００ｋｇ·ｄ－１以下者。结论：氯氮平的治疗剂量以不超过４００ｋｇ·ｄ－１是较为安全的。
Objective: To observe and evaluate the dosage and side effects of clozapine in the treatment of schizophrenia patients. Methods: Forty-five inpatients with schizophrenia were enrolled in this study. Their physical and laboratory tests were normal at admission and were treated with clozapine either alone or in combination. The dosage of the drug and the adverse reactions after taking the drug were evaluated Statistical analysis and comparison. Results: The extrapyramidal reaction was found in 28.7%. In addition, the leukocyte reduction rate of clozapine dose more than 400kg · d-1 was significantly higher than that of the dose less than 400kg · d-1. CONCLUSIONS: Clozapine is safe for doses up to 400 kg · d-1.