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许多证据提示,松果腺在青春期发育中起一定作用。例如,松果腺肿瘤常伴发异常的青春期提前;在发育期间血浆褪黑激素水平和尿6-硫氧褪黑激素排泄均减低。 本文作者报告1例因颅咽管瘤引起的幼稚型(婴儿型Infantilism)患者,在雌激素诱发第二性征期间,作为褪黑激素产生主要指标的尿硫氧褪黑激素迅速减少。患者为17岁女孩,表现幼稚型,特征是身材矮小、原发性闭经、青春期延迟、腋毛及阴毛稀少、乳房发育不良。身高154cm、体重37.5kg、血清雌激素0.1nmol/1以下,黄体激素
Many evidence suggests that pineal gland plays a role in puberty. For example, pineal gland tumors are often associated with abnormal adolescent advancement; plasma melatonin levels and urinary 6-thiourea-melatonin excretion are reduced during development. The authors report a rapid decrease in urinary thioxymelatonin, a major indicator of melatonin production, during a second sexual phase induced by estrogen in a case of naïve Infantilism caused by craniopharyngioma. The patient, a 17-year-old girl, was infantile and characterized by short stature, primary amenorrhea, delayed puberty, rare armpit hair and pubic hair, and poorly developed breasts. Height 154cm, weight 37.5kg, serum estrogen 0.1nmol / 1 the following, luteinizing hormone