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目的比较两组短程小剂量方案奥美拉唑+阿莫西林+甲硝唑(OAM)方案及雷尼替丁+丽珠得乐+阿莫西林+甲硝唑(RBAM)方案根治幽门螺杆菌(Hp)相关十二指肠溃疡的疗效。方法采用随机对照临床试验,经胃镜检查、快速尿素酶试验(RUT)证实Hp感染的十二指肠溃疡患者74例,随机分为两组:A组用OAM方案,B组用RBAM方案,均治疗7天,抑酸剂续用3周。随访6～8周后复查胃镜和RUT观察溃疡愈合及Hp根治情况。结果 74例患者完成治疗及随访。两组的Hp根除率分别为90.63%和80.95%(P>0.05)。两组溃疡愈合率分别为100%和92.86%(P>0.05)。所有患者均能耐受治疗,未发现严重副作用。但完成A组方案费用(638元)明显高于B组(100元)。结论 Hp感染的十二指肠溃疡患者,上述两种方案均可选用。基层医院对经济拮据者可选用后一种方案。
Objective To compare the effects of omeprazole + amoxicillin + metronidazole (OAM) and ranitidine + rituximab + amoxicillin + metronidazole (RBAM) (Hp) -related duodenal ulcer. Methods 74 patients with duodenal ulcer with Hp infection confirmed by gastroscopy and rapid urease test (RUT) were randomly divided into two groups: group A with OAM and group B with RBAM Treatment for 7 days, acid suppression continued for 3 weeks. After 6 to 8 weeks of follow-up, gastroscopy and RUT were performed to observe the healing of ulcer and the radical cure of Hp. Results 74 patients completed the treatment and follow-up. Hp eradication rates were 90.63% and 80.95% in both groups (P> 0.05). The healing rates of ulcer in both groups were 100% and 92.86%, respectively (P> 0.05). All patients were well tolerated and found no serious side effects. However, the cost of completing program in group A (638 yuan) was significantly higher than that of group B (100 yuan). Conclusion Hp infection in patients with duodenal ulcer, the above two options are available. The latter can choose the latter solution to the economic shortage.