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目的 观察高强度聚焦超声 (HIFU)治疗前后恶性肿瘤病人外周血免疫细胞数量变化。方法 采用流式细胞技术 ,测定 36例恶性肿瘤病人HIFU治疗前及治疗后 1～ 2周外周血CD3+ 、CD4 + 、CD8+ 、CD19+及CD(16 + +5 6 + )细胞数量的变化。自身配对t检验分析检测结果。结果 与治疗前比较 ,HIFU治疗后肿瘤病人外周血CD4 + 数 (P =0 0 0 9)和CD4 /CD8(P =0 0 12 )明显增加 ;治疗后外周血CD3+ 数轻度增加 ,CD8+ 、CD19+ 和CD(16 + +5 6 + )数轻度下降 ,但与治疗前比较无统计学意义。结论 HIFU治疗后恶性肿瘤病人免疫机能增强。
Objective To observe the changes of peripheral blood immune cells in malignant tumor patients before and after high intensity focused ultrasound (HIFU) treatment. Methods Flow cytometry was used to determine the number of CD3 +, CD4 +, CD8 +, CD19 + and CD (16 + +5 6 +) cells in peripheral blood of 36 malignant tumor patients before and after treatment with HIFU. Paired t test analysis of their own test results. Results Compared with that before treatment, the number of CD4 + (P = 0 0 0 9) and CD4 / CD8 (P = 0 0 12) in the peripheral blood of patients with HIFU increased significantly after treatment. The CD3 + The numbers of CD19 + and CD (16 + +5 6 +) decreased slightly, but there was no statistical significance before treatment. Conclusion The immune function of malignant tumor patients after HIFU treatment is enhanced.