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目的探讨乳杆菌制剂治疗外阴阴道假丝酵母菌病(VVC)的疗效。方法将2006年5月至7月在温州医学院附属二院确诊为VVC的患者分为3组,单纯使用达克宁栓者(A组)40例,联合使用达克宁栓及定君生阴道栓者(B组)40例,单纯使用定君生者40例(C组),进行对照。对3组的临床症状及真菌学检查结果进行分析讨论。结果停药3~5 d时,A、B组患者的疗效差异无显著性(P>0.05),C组患者的疗效明显低于A、B两组(P<0.05);停药30~37 d时,A、C组患者的疗效差异无显著性(P>0.05),B组患者的疗效明显高于A、C两组(P<0.05)。结论在应用阴道用乳杆菌治疗VVC时,应首先应用抗真菌药物,当真菌感染得以控制之后再使用乳杆菌,帮助恢复阴道内菌群环境。
Objective To investigate the efficacy of Lactobacillus preparations in the treatment of vulvovaginal candidiasis (VVC). Methods The patients diagnosed as VVC in the Second Affiliated Hospital of Wenzhou Medical College from May 2006 to July 2006 were divided into 3 groups: 40 patients in group A were treated with combination of metronidazole, B group) 40 cases, the use of pure monarch 40 cases (C group), for comparison. Three groups of clinical symptoms and mycological examination results were analyzed and discussed. Results There was no significant difference in the efficacy between group A and group B (P> 0.05) after 3 to 5 days of withdrawal. The efficacy of group C was significantly lower than that of group A and B (P <0.05) There was no significant difference in the therapeutic effect between group A and C (P> 0.05). The effect of group B was significantly higher than that of group A and C (P <0.05). Conclusion In the treatment of VVC with Lactobacillus vaginalis, the antifungal drug should be applied first, and when the fungal infection is controlled, Lactobacillus is used again to help restore the vaginal flora environment.