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Stat3是重要的信号转导与转录因子,与细胞的异常增殖密切有关,很多研究表明,Stat3在恶性肿瘤组织和肿瘤细胞中异常表达。近年来,STAT3信号通路在恶性肿瘤中的作用越来越受重视,参与恶性肿瘤的发生、发展、侵袭和转移,已经成为临床治疗的靶基因。信号通路中Stat3能被多种因子激活,活化后的Stat3转录激活下游的靶基因,进一步引起一系列相关因子的激活和蛋白的表达,促进恶性肿瘤的发展、侵袭和转移。但是,STAT3信号通路对恶性肿瘤的发生、发展、侵袭和转移的整个过程的具体作用机制还不十分明确,有待进一步研究。
Stat3 is an important signal transduction and transcription factor, which is closely related to the abnormal proliferation of cells. Many studies have shown that Stat3 is abnormally expressed in malignant tumor tissues and tumor cells. In recent years, the role of STAT3 signaling pathway in malignant tumors has gained more and more attention. It is involved in the occurrence, development, invasion and metastasis of malignant tumors and has become the target gene for clinical treatment. Stat3 can be activated by a variety of factors in the signaling pathway. Activated Stat3 transcription activates downstream target genes, further activating a series of related factors and protein expression, and promoting the development, invasion and metastasis of malignant tumors. However, the specific mechanism of action of STAT3 signaling pathway in the whole process of malignant tumorigenesis, development, invasion and metastasis is not yet clear enough to be further studied.