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目的观察PTEN在胃癌组织当中的表达,探讨其与胃癌发生的联系及其临床意义。方法采用免疫组化方法检测PTEN蛋白在胃癌组织和正常胃黏膜中的表达。结果PTEN在正常胃黏膜和胃癌中阳性率分别为100%,64.4%。PTEN表达与胃癌的分化程度高低、浸润深度、是否有淋巴结转移和临床分期关系密切(P<0.05),与患者年龄、肿瘤部位无关(P>0.05)。结论PTEN的异常表达可为胃癌诊断和判断其生物学特性提供可靠的指标。
Objective To observe the expression of PTEN in gastric carcinoma and to explore its relationship with gastric carcinogenesis and its clinical significance. Methods The expression of PTEN protein in gastric cancer and normal gastric mucosa was detected by immunohistochemistry. Results The positive rates of PTEN in normal gastric mucosa and gastric cancer were 100% and 64.4% respectively. The expression of PTEN was correlated with the degree of differentiation, depth of invasion, lymph node metastasis and clinical stage (P <0.05), but not with age and tumor location (P> 0.05). Conclusion The abnormal expression of PTEN may provide a reliable indicator for the diagnosis of gastric cancer and its biological characteristics.