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老周喜欢每日喝上几杯酒,自得其乐。近几日来,清晨刷牙时总是牙龈出血,特别是搬桌子时小腿碰撞了一下,就见碰处青紫一大片。老周到门诊部检查,化验结果显示出凝血时间延长,凝血酶原时间延长,表明老周有凝血机制障碍。医生告诉老周,这种情况可能是长期饮酒导致维生素 K 利用障碍引起的。医生解释道:酒精主要成分为乙醇。乙醇吸入肝脏后,在其未被肝脏水解前能够抑制维生素 K 的凝血因子的合成。此外,乙醇还能抑制内双香豆素与血浆蛋白的结合,使双香豆素解离出
Old Week like to drink a few glasses of wine daily, enjoy themselves. In recent days, bleeding gums are always brushing your teeth early in the morning, especially when the calf collides with the table for a while, and you see a large area of bruising. The old week out to the clinic examination, test results showed that clotting time, prothrombin time, indicating that the old clotting mechanism disorders. The doctor told the old week, this situation may be caused by long-term consumption of vitamin K utilization disorders. The doctor explained: alcohol is the main component of ethanol. After ethanol is inhaled into the liver, it inhibits the synthesis of vitamin K-containing clotting factors before it is hydrolyzed by the liver. In addition, ethanol also inhibits the binding of endocoumins to plasma proteins and causes dicoumarol to dissociate