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目的 :研究葡苷聚糖对正常人体肠道生理功能、大便中短链脂肪酸和厌氧杆菌含量的变化的影响。方法 :90例健康志愿者连续 30天摄入不同量的葡苷聚糖 ,观察肠道生理功能 (排便频数 ,大便软化程度和粪便 p H值等 )改变 ,并用氨基酸分析仪和细菌培养方法测定大便中短链脂肪酸和厌氧杆菌含量的变化。结果 :( 1)葡苷聚糖能使大便排泄通畅 ,粪便软化 ,每日大便量增加和肠道内 p H值下降 ;( 2 )粪便中乙酸盐、丁酸盐和异丁酸盐含量上升 ;( 3)粪便中乳酸杆菌和双歧杆菌的繁殖明显增多 ,肠道致病菌受到明显抑制。结论 :每日摄入 8～ 12克的葡苷聚糖能使肠道生理功能和相关的生化指标改善达到理想水平 ,有助于肠道多种疾病的预防和治疗
Objective: To study the effect of glucosan on the changes of intestinal physiological function, short-chain fatty acids and anaerobic bacteria content in normal human. Methods: Ninety healthy volunteers were given different amounts of glucosinolates for 30 consecutive days. The changes of intestinal physiological function (defecation frequency, stool softening degree and stool p H value) were observed and determined by amino acid analyzer and bacterial culture Changes of Contents of Short Chain Fatty Acids and Anaerobic Bacteria in Stool. Results: (1) glucosinolates can make stool excretion smooth, stool softening, increased daily stool volume and intestinal p H value decreased; (2) stool acetate, butyrate and isobutyrate increased ; (3) Lactobacillus and bifidobacteria in stool significantly increased the number of reproduction, intestinal pathogens were significantly inhibited. CONCLUSION: Daily intake of 8-12 g of glucosaminoglycan can improve the intestinal physiological function and related biochemical indicators to the ideal level, which is helpful for the prevention and treatment of various intestinal diseases