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用Golgi法研究大鼠视交叉上核(SCN)的生后发育,可分为两个阶段。第一阶段(新生至生后5d),神经元快速生长和分化,树突由粗短变为纤细,伴有串珠状膨大,丝状突起和生长锥,小棘始基出现。第二阶段(生后6～31d),神经元生长发育和成熟阶段,表现在串珠状膨大,丝状突起和生长锥的消长变化,小棘始基转变为蘑菇形结构。电镜观察结果,在生后三周内,神经元胞质进行性增加,细胞器逐渐丰富,第二周末突触数量显著增加,且形式多样。
The Golgi method to study the development of the suprachiasmatic nucleus (SCN) in rats can be divided into two stages. In the first phase (newborn to postnatal day 5), neurons rapidly grew and differentiated. The dendrites changed from short and thin to slim, accompanied by beaded enlargement, filiform protrusions and growth cones, and small spinous roots. In the second stage (6 ~ 31 days after birth), the growth and development of neurons were characterized by beaded swollen growth, changes of growth and formation of filamentous protrusions and growth cones, and the transformation of small spines into mushroom-shaped structures. Electron microscopy showed that within three weeks after birth, neuronal cytoplasm increased progressively, organelles gradually enriched, and the number of synapses increased significantly in the second weekend with various forms.