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许多血清催乳素水平升高的生理及病理情况通常伴有无排卵及闭经,但高催乳素血症时无排卵的发病机理并未弄清,有报导在闭经溢乳和在Shlpiride引起的高催乳素血症时,雌激素反馈异常。本文观察口服Sulpiride引致高催乳素血症的月经正常妇女注射雌激素后的促性腺素释放反应。作者在5例周期规律,催乳素水平正常的妇女于周期第6～16天给予口服Sulpiride150mg/日(50mg tid),引起中度高催乳素血症,从而研究雌激素对促性腺释放的反馈作用。对服用Sulpiride3～18个月(150mg/日)有慢性明显高催乳素血
Many physiological and pathological changes of serum prolactin levels are usually accompanied by anovulation and amenorrhea, but the pathogenesis of anovulation in hyperprolactinemia is not clear, there are reports of amenorrhea galactorrhea and Shlpiride-induced hyperprolactine Hyperlipidemia, estrogen feedback abnormalities. This article observes oral administration of Sulpiride induced hyperprolactinemia normal menstrual injection of estrogen after gonadotropin-releasing response. The authors studied the effects of estrogen on gonadotropic release in 5 patients with normal prolactin levels on 5 cycles of oral Sulpiride 150 mg / day (50 mg tid) administered on days 6-16 of the cycle, resulting in moderate hyperprolactinemia . Sulpiride taking 3 ~ 18 months (150mg / day) with chronic hyperprolactinemia blood