论文部分内容阅读
目的 探讨阿苯达唑减量法及外科降颅压措施治疗重度脑囊尾蚴病的方法。 方法 74例重度脑囊尾蚴病患者经脑CT和 /或磁共振成像 (MRI)证实囊尾蚴数为 10 0～ 1160个。先用阿苯达唑减量法找到初始耐受剂量 ,之后逐渐递增到治疗剂量 (口服阿苯达唑每天 2 0mg/kg ,分 3次服用 ,10d为 1疗程 ,共 3～ 4疗程 )。服药治疗期间同时用降颅压药物和抗癫痫药。使用药物降颅压无效者行外科降颅压治疗。 结果 74例患者服用阿苯达唑后 ,经药物降颅压有效者 7例 ,无效者 67例。无效者 ,经脑室外引流术治疗 48例 ,脑室外引流加颞肌减压术治疗 19例。 67例经手术降颅压治疗的患者 ,除 1例外皆可耐受阿苯达唑治疗。 74例患者中随访 70例 ,随访期为 19～ 5 2个月 (平均3 7 2月 )。随访中经复查CT或MRI ,除 1例 (囊尾蚴数达 1160个 )治疗失败外 ,其余 69例均临床治愈。 结论 阿苯达唑减量法并行降颅压药物或外科降颅压治疗重度脑实质囊尾蚴病 ,是安全、有效的治疗方法
Objective To investigate the method of reduction of albendazole and surgical reduction of intracranial pressure in the treatment of severe cerebral cysticercosis. Methods 74 patients with severe cerebral cysticercosis were confirmed by CT and / or magnetic resonance imaging (MRI). The number of cysticerci was 10 ~ 1160. First with albendazole reduction method to find the initial tolerated dose, and then gradually increased to the therapeutic dose (oral albendazole daily 20mg / kg, taking 3 times, 10d for a course of treatment, a total of 3 to 4 courses). Medication during treatment with reduced intracranial pressure drugs and anti-epileptic drugs. The use of drugs to reduce intracranial pressure ineffective surgical reduction intracranial pressure treatment. Results After taking albendazole in 74 patients, there were 7 cases effective in reducing intracranial pressure and 67 cases were ineffective. Invalid, 48 cases were treated by extracerebroventricular drainage, ventricular extracranial drainage and temporal muscle decompression in the treatment of 19 cases. Sixty-seven patients who underwent intracranial craniotomy were able to tolerate albendazole except one. Of the 74 patients, 70 were followed up for 19-52 months (average 372 months). Follow-up by CT or MRI after review, except for 1 case (cysticercus number 1160) failed to treat the other 69 cases were clinically cured. Conclusions Albendazole concurrent reduction of intracranial pressure drugs or surgical intracranial pressure in the treatment of severe cerebral palsy cysticercosis, is a safe and effective treatment