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目的研究2型糖尿病的高效造模方案。方法采用高糖高脂与链脲佐菌素联用制作糖尿病模型,通过大鼠血糖和生活表现来评定方案的优缺性。结果高糖高脂饲料按比例喂养后,加用链脲佐菌素腹腔注射多次,可很好的在大鼠中建立2型糖尿病模型。结论高糖高脂联合链脲佐菌素可成功制作糖尿病模型。
Objective To study the efficient modeling of type 2 diabetes. Methods High-fat and high-fat streptozotocin combined with streptozotocin in the production of diabetic model, through the blood glucose and life performance of rats to assess the advantages and disadvantages of the program. Results After high-fat and high-fat diet were fed in proportion, streptozotocin plus intraperitoneal injection of streptozotocin multiple times could well establish type 2 diabetes model in rats. Conclusion High glucose and high fat combined with streptozotocin can make diabetes model successfully.