论文部分内容阅读
通过建立稳定大鼠哮喘模型，观测其肺功能的变化。方法：SD大鼠随机分4组，正常对照组；致敏组；即刻激发组；连续激发组。分别测定肺功能变化。结果：致敏组肺功能无改变，哮喘两组经卵蛋白激发后，肺功能均有显著性改变。气道压力（P，cmH2O）增高111．93％－160.89％，气道阻力（Raw,cmH2O.mL/s）增加264．22％－241．93（P＜0．01），哮喘两组比较无显著性差异（P＞0．05）。结论：本研究成功地建立大鼠哮喘模型，并对大鼠哮喘不同病情程度的肺功能有了新的认识。
By establishing a stable rat asthma model, observed changes in lung function. Methods: SD rats were randomly divided into 4 groups, normal control group; sensitized group; immediate excitation group; continuous excitation group. Respectively measured changes in lung function. Results: There was no change in pulmonary function in the sensitized group. The lung function of both groups after asthma challenged by ovalbumin was significantly changed. Airway pressure (P, cmH2O) increased by 111.93% -160.89%, airway resistance (Raw cmH2O.mL / s) increased by 264.22% -241.93 (P <0.01) No significant difference (P> 0.05). Conclusion: This study successfully established a rat model of asthma and a new understanding of lung function in rats with different severity of asthma.