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目的探讨外周血淋巴细胞计数与RA患者感染的相关性,为RA患者合并感染的防治提供临床依据。方法分析嘉兴市第一医院2004年1月-2008年12月住院RA患者319例,其中,男性75例,女性244例,平均年龄57.1±13.1(20~88)岁;平均病程10.5±8.0(3个月~40年)年。感染组104例,非感染组215例。检测项目包括外周血白细胞、淋巴细胞、中性粒细胞计数、血红蛋白、血小板、红细胞沉降率、C-反应蛋白、类风湿因子和淋巴细胞亚群。计量资料以均数±标准差表示,组间比较采用t检验。结果与非感染组RA患者比较,感染组患者的年龄大、男性多、病程长、ESR快、CRP和中性粒细胞增多以及血红蛋白、淋巴细胞计数减低差异有统计学意义,其中,淋巴细胞计数与感染呈显著性负相关(r=0.701,P<0.01);而类风湿因子、外周血白细胞、血小板在感染组与非感染组之间差异无统计学意义。结论RA患者感染的危险因素包括年龄大、男性、病程长、ESR快、CRP升高、中性粒细胞增多、贫血,外周血淋巴细胞计数与感染呈显著性负相关。
Objective To investigate the correlation between peripheral blood lymphocyte counts and the infection of RA patients and provide the clinical evidence for the prevention and treatment of the co-infection in RA patients. Methods A total of 319 inpatients with RA were enrolled in the First Affiliated Hospital of Jiaxing from January 2004 to December 2008, including 75 males and 244 females, with an average age of 57.1 ± 13.1 (range, 20 to 88 years) and an average duration of 10.5 ± 8.0 (range, 3 months to 40 years) years. Infection group 104 cases, 215 cases of non-infected group. Test items include peripheral blood leukocytes, lymphocytes, neutrophil counts, hemoglobin, platelets, erythrocyte sedimentation rate, C-reactive protein, rheumatoid factor and lymphocyte subsets. Measurement data to mean ± standard deviation, comparison between groups using t test. Results Compared with non-infected RA patients, the infected patients were older, more men, longer duration, fast ESR, CRP and neutrophils increased, and hemoglobin, lymphocyte count decreased significantly, including lymphocyte count (R = 0.701, P <0.01). There were no significant differences in rheumatoid factor, peripheral white blood cells and platelets between infected and non-infected groups. Conclusion The risk factors of infection in RA patients include age, male, long course of disease, fast ESR, elevated CRP, neutrophilia, anemia, peripheral blood lymphocyte count and infection were significantly negatively correlated.