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目的感染性脑膜炎是儿科常见病及多发病之一,严重影响儿童健康。对不典型起病或经过不正规治疗的患者,诊断往往较困难。而及时的诊断对改善预后、减少后遗症非常重要,为了有效的鉴别化脓性或病毒性脑膜炎,笔者总结了本院近年来儿童感染性脑膜炎诊治后期的脑脊液的情况并加以分析,期望对临床工作有所帮助。方法收集本院2003-2007年经本院确诊的细菌性脑膜炎治疗后一周的患者和临床病毒性脑炎的患者,分别于7天、14天、21天进行了脑脊液中CRP、IL-6、TNF的测定,并进行统计。结果儿童急性细菌性脑膜炎患者脑脊液CRP、IL-6、TNF与病毒性脑炎相比差异有统计学意义。结论结合临床症状和有效的检查脑脊液中CRP、IL-6、TNF量化指标,可进一步增加鉴别两种脑膜炎的敏感性,明显提高化脓性脑膜炎的诊断价值和准确性,有利于减少误诊,增强治疗的针对性。
Objective Infectious meningitis is one of the common pediatric diseases and frequently-occurring diseases, seriously affecting children’s health. Of atypical onset or after treatment of patients with irregular, the diagnosis is often more difficult. In order to effectively identify purulent or viral meningitis, the author summarizes and analyzes the situation of cerebrospinal fluid in the late stage of diagnosis and treatment of children’s infectious meningitis in our hospital in recent years, and expects that clinical diagnosis Work helps. Methods Patients in our hospital from 2003 to 2007 and one week after treatment of bacterial meningitis in our hospital and patients with clinical viral encephalitis were enrolled in this study. The levels of CRP and IL-6 in cerebrospinal fluid were measured at 7 days, 14 days and 21 days respectively. , TNF determination, and statistics. Results The levels of CRP, IL-6 and TNF in cerebrospinal fluid of children with acute bacterial meningitis were significantly different from those of viral encephalitis. Conclusion Combined with clinical symptoms and effective examination of quantitative indicators of cerebrospinal fluid CRP, IL-6, TNF can further increase the sensitivity of the differential diagnosis of two meningitis, significantly improve the diagnostic value and accuracy of purulent meningitis is helpful to reduce misdiagnosis, Enhance the treatment of targeted.