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某些观点认为Ｔ＿（Ｈ１）型和Ｔ＿（Ｈ２）型应答不平衡有助于ＨＩＶ感染时免疫失调。抵抗ＨＩＶ感染和／或阻止其进展为ＡＩＤＳ，有赖于Ｔ＿（Ｈ１）＞Ｔ＿（Ｈ２）的优势。这一假说是基于下列发现作出的：①进展为ＡＩＤＳ时，ＴＬ－２和ＩＦＮ－γ产生能力丧失同时却有ＩＬ－４和ＩＬ－１０产生增加；②许多血清学阴性的ＨＩＶ接触者对ＨＩＶ抗原表现强烈的Ｔ＿（Ｈ１）型免疫应答。
Some people think that imbalance of T_ (H1) and T_ (H2) responses can help immune imbalance in HIV infection. Resistance to HIV infection and / or prevention of its progression to AIDS depend on the advantages of T H1 (H1)> T H2 (H2). This hypothesis is based on the following findings: ① progression to AIDS, TL-2 and IFN-γ production capacity at the same time there is an increase in IL-4 and IL-10; ② many seronegative HIV contacts on HIV Antigen T_ (H1) type immune response.