雷帕霉素靶蛋白(mTOR)是一种非典型的丝氨酸/苏氨酸蛋白激酶,对机体细胞的生长、代谢有调节作用。mTOR在哺乳动物中形成两种蛋白复合物,mTORC1和mTORC2,均可调节糖脂代谢。Rictor是雷帕霉素靶蛋白复合物2(mTORC2)的核心蛋白之一,可通过mTORC2直接磷酸化Akt调节糖代谢。当Rictor缺乏时,会通过影响胰岛素信号传导通路、胰岛β细胞的增殖和凋亡等造成葡萄糖耐受不良。 Rapamycin target protein (mTOR) is an atypical serine / threonine protein kinase that regulates cell growth and metabolism. mTOR forms two protein complexes in mammals, both mTORC1 and mTORC2, which regulate glycolipid metabolism. Rictor, one of the core proteins of rapamycin target protein complex 2 (mTORC2), regulates glucose metabolism by direct phosphorylation of Akt by mTORC2. When Rictor is deficient, glucose tolerance is impaired by influencing insulin signaling pathways, proliferation and apoptosis of islet beta cells, and the like.