神经原特异性烯醇化酶(Neuron-spe-cific Enolase,NSE)是近10年来人们所关注的一种新的肿瘤标记物,烯醇化酶(Enolase)系糖酵解的2-磷酸甘油与2-磷酸烯醇式丙酮酸代谢过程的催化酶,分布于全身各组织中。其分子量约5万,结构有α、β、γ3种亚基的异构酶,γ-Enolase 仅存在于神经细胞及轴突中,不存在于胶质细胞中,故称为NSE;从而NSE 的分子结构有γ,γ-NSE 及α、γ-NSE 两型。自Rider 等(1975)发现γ-Enolase 之后,Boch 及Marangos 等认为它与神经组织特 Neuron-spe-cific Enolase (NSE) is a new tumor marker of interest in the past 10 years. Enolase is glycolytic 2-phosphoglycerol and 2 - The enzyme that catalyzes the metabolism of phosphoenolpyruvate is distributed throughout tissues of the body. Its molecular weight is about 50,000, an isomerase structure of α, β, γ three subunits, γ-Enolase exists only in nerve cells and axons, does not exist in glial cells, it is called NSE; thus NSE Molecular structure of γ, γ-NSE and α, γ-NSE two types. After γ-Enolase was discovered by Rider et al. (1975), Boch and Marangos et al.