患者女性,32岁。因间断发烧、周身不适、食欲减退、体重减轻、腹痛及腹泻3周入院。患者于发病前3个月到巴基斯坦旅行,病前1周才返回。此期间内,其3岁的儿子患病,疑为沙门氏菌感染。患者出国前2周曾接受天花、霍乱疫苗注射,但未接种伤寒、副伤寒疫苗,未接受预防性抗疟剂。入院前她被隔离治疗的4天中,用过先锋霉素、羟氨苄青霉素、氯喹,但无临床症状的改善。否认有呼吸道和关节症状。未见皮疹。 T 38℃。P 90次/分。肝脾肿大,质地软。胸部正常。血红蛋白14.0g/dl,白细胞5500/mm~3,中性粒细胞50%,淋巴细胞40%,单核细胞10%。血沉31mm/第1小时。镰状细胞试验阴性。血涂片查疟原虫3次阴性。血、尿培养2次阴性,粪便培养1次阴性,肝活体组织培养阴性。入院后第3天做胸骨骨髓穿刺。骨髓直接培养阴性。用0.1%葡萄糖肉汤传代培养后5天生长了噬菌 Patient female, 32 years old. Due to intermittent fever, discomfort, loss of appetite, weight loss, abdominal pain and diarrhea 3 weeks admitted. Patient travels to Pakistan 3 months prior to onset and returns only 1 week before illness. During this period, his 3-year-old son was ill and was suspected of being Salmonella. Patients were vaccinated with smallpox and cholera vaccination 2 weeks before leaving the country but were not vaccinated against typhoid and paratyphoid and did not receive prophylactic antimalarial. She had been treated with cephalosporin, amoxicillin, and chloroquine for 4 days prior to admission but had no clinically significant improvement. Denied having respiratory and joint symptoms. No rash. T 38 ° C. P 90 beats / min. Hepatosplenomegaly, soft texture. Chest normal. Hemoglobin 14.0g / dl, white blood cells 5500 / mm ~ 3, 50% of neutrophils, lymphocytes 40%, monocytes 10%. ESR 31mm / first hour. Sickle cell test negative. Blood smear check Plasmodium 3 negative. Blood, urine culture 2 negative, stool culture 1 negative, liver biopsy negative. On the 3rd day after admission, the sternal bone marrow was punctured. Direct bone marrow culture negative. Phages were grown 5 days after subculturing with 0.1% glucose broth