用三氟甲基磺酸-4-三甲基铵苯甲醛作标记前体制备了一种用途广泛的18F标记中间体4-[18F]氟苯甲醛,并用正交实验法对标记条件进行了优化。在最佳标记条件下,其合成时间为45 min,标记率为62.1%,放化产率为56.5%(衰变校正)。标记物经Sep-Pak Plus C18柱纯化后,放化纯度大于95%。 A new 18F-labeled intermediate, 4- [18F] fluorobenzaldehyde, was synthesized using 4-trimethylammonium benzaldehyde as a labeling precursor. The labeling conditions were determined by orthogonal design optimization. Under the best labeling conditions, the synthesis time was 45 min, the labeling rate was 62.1%, and the radiochemical yield was 56.5% (decay correction). After purification on a Sep-Pak Plus C18 column, the radiochemical purity was greater than 95%.