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目的观察不同剂量鼠神经生长因子联合神经节苷酯对婴儿脑损伤后神经功能修复的促进作用。方法 90例脑损伤患儿分为试验组和对照组,各45例。对照组在对症治疗的基础上肌内注射鼠神经生长因子30μg+静脉滴注神经节苷酯,试验组在对症治疗的基础上肌内注射鼠神经生长因子18μg+静脉滴注神经节苷酯,连续治疗14 d。比较2组患儿治疗后的临床症状、神经功能评分和智力水平。结果治疗7,14 d后,试验组患儿的神经功能性评分为(33.80±1.80),(38.20±1.90)分,与对照组的(32.20±2.40),(37.40±2.10)分,差异无统计学意义(P>0.05)。试验组神经功能改善方面的总有效率为95.56%(43/45例),与对照组的91.11%(41/45例)差异无统计学意义(P>0.05)。治疗后,试验组患儿的智力水平和脑损伤临床症状的改善与对照组差异无统计学意义(P>0.05)。不良反应主要表现为恶心呕吐和躁动,2组不良反应发生率差异无统计学意义(P>0.05)。结论低剂量的鼠神经生长因子联合神经节苷酯同样有利于婴儿脑损伤后的神经功能修复。
Objective To observe the effects of different doses of nerve growth factor combined with ganglioside on neurological function in infants with brain injury. Methods Ninety children with brain injury were divided into experimental group and control group, with 45 cases each. On the basis of symptomatic treatment, the control group was intramuscularly injected with 30 μg of mouse nerve growth factor and intravenous infusion of ganglioside. The experimental group was treated with intramuscular injection of 18 μg of nerve growth factor and intravenous ganglioside intramuscularly on the basis of symptomatic treatment for continuous treatment 14 d. The clinical symptoms, neurological function score and intelligence level were compared between the two groups after treatment. Results After 7 and 14 days of treatment, the neurological functional scores of the experimental group were (33.80 ± 1.80) and (38.20 ± 1.90) points respectively, compared with those in the control group (32.20 ± 2.40 and 37.40 ± 2.10) Statistical significance (P> 0.05). The total effective rate in improving the neurological function in the experimental group was 95.56% (43/45 cases), which was not significantly different from that in the control group (91.11%, 41/45 cases) (P> 0.05). After treatment, there was no significant difference between the experimental group and the control group in the mental status and the clinical symptoms of the brain injury (P> 0.05). Adverse reactions mainly manifested as nausea and vomiting and agitation, the incidence of adverse reactions was no significant difference between the two groups (P> 0.05). Conclusions Low doses of NGF and ganglioside also benefit neurological repair after brain injury in infants.