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目的探讨尿Ｇ１细胞的形成机制及其在血尿定位诊断中的意义。方法系统观察尿液不同渗透压、ｐＨ值及模拟肾小管渗透压动态变化在Ｇ１细胞形成过程中作用。结果正常红细胞经历模拟肾小管的渗透压动态变化过程且终末尿渗透压达６４０ｍｍｏｌＬ－１后出现Ｇ１细胞，终末尿渗透压愈高，Ｇ１细胞所占的比例愈大；而当渗透压或ｐＨ值固定不变时，则无论其值如何，均不会出现Ｇ１细胞。结论终末尿渗透压超过６４０ｍｍｏｌＬ－１，Ｇ１细胞是较可靠的肾小球性血尿诊断指征；在应用尿红细胞形态检查判断血尿来源时，应同时测定尿液渗透压，综合分析肾小管浓缩稀释功能及其它指标，以提高诊断准确率
Objective To investigate the formation mechanism of urinary G1 cells and its significance in the diagnosis of hematuria. Methods The changes of urine osmotic pressure, pH value and simulated changes of tubule osmotic pressure were systematically observed in G1 cell formation. Results The normal erythrocytes underwent the process of simulating the dynamic change of the tubal osmotic pressure. The G1 cell appeared after the terminal urinary osmotic pressure reached 640mmolL-1. The higher the terminal urinary osmotic pressure, the greater the proportion of G1 cells. When the osmotic pressure or At constant pH, G1 cells do not appear regardless of their value. Conclusions The final urinary osmotic pressure is higher than 640mmolL-1. G1 cell is a reliable indicator of the diagnosis of glomerular hematuria. Urine osmotic pressure should be determined simultaneously when urinary erythrocyte morphology is used to determine the origin of urine. Comprehensive analysis of renal tubular concentration Dilution function and other indicators to improve diagnostic accuracy