通过多中心前瞻性协作研究,对国产盐酸曲玛多在癌症疼痛、手术后疼痛、牙痛和分娩疼痛的镇痛效果共500例作了观察,并应用安慰剂、强痛定、灶冷丁及进口曲马多在444例中作了同期或自身对比研究。结果表明:对前3种疼痛均有良好的疗效,有效率在733～97.9%之间,对分娩疼痛有效率也达55%,与进口药相同。此药副作用轻微,疗效优于强痛定,为一较好的非吗啡类镇痛药。 A multicenter prospective collaborative study of domestic tramadol hydrochloride in cancer pain, postoperative pain, toothache and labor analgesic effect of pain were observed in 500 cases, and the use of placebo, Qiangtong Ding, Zao Ding and imports Tramadol in 444 cases made a contemporaneous or self-comparative study. The results showed that: the first three kinds of pain have a good effect, the effective rate between 733 ~ 97.9%, the effective rate of labor pain also reached 55%, and import drugs the same. The side effects of this medicine is mild, the effect is superior to the strong pain, a better non-morphine analgesics.